Lunes, Mayo 14, 2012

Introduction to Endocrinology


Endocrinology; What is it?


         Endocrinology is the study of hormones including diseases and conditions related or associated with hormonal imbalance. The endocrine system which is a finely integrated system continually communicate through feedback inhibition and stimulation to control all aspects of metabolism, growth and reproduction. Through this, it is possible to characterize an underlying  abnormality and provide treatment.

Questions regarding growth and development can now be addressed by studying  the changing pattern of hormones. It is a known truth that the endocrine system regulates our mood, growth and maturity, tissue function, metabolism as well as sexual and reproductive function.
For sure it will tickle our mind and imagination for what seems to be a dry, boring subject is a wonderful subject very interesting and educational.



Figure 1

Photo credit: 


Major Endocrine Glands and Hormones




glands
HORMONES
GLAND/HORMONE FUNCTION
SOME DISORDERS
Hypothalamus
(Lower middle of the brain)
Growth hormone-releasing hormone (GHRH)

Thyrotropin-releasing hormone (TRH)

Corticotropin-releasing hormone (CRH)

Gonadotropin-releasing hormone (GnRH)

Prolactin-(PRL)


Antidiuretic Hormones- (ADH)
Communicates with both nervous and endocrine systems.

Stimulates (GHRH, TRH, CRH, GnRH) or inhibits (PIF) hormone production in the pituitary










Water balance
















Precocious puberty (early GnRH production)

Kallman syndrome (inadequate GnRH production)
Pituitary
(below hypothalamus, behind sinus cavity)
Prolactin







Growth Hormone





ACTH


TSH



LH, FSH
Milk production
Bone growth












Stimulates cortisol


Stimulates thyroid
Regulation of testosterone and estrogen, fertility
Hypopituitarism
   Empty Sella Syndrome
   Galactorrhea




Acromegaly or Gigantism (excess GH)
Growth Hormone Deficiency (GHD)


Cushing disease (excess ACTH)


Hyper/Hypothyroidism (TSH)


Loss of menstrual period

Loss of sex drive

Infertility


Thyroid
(butterfly shaped,
Lies flat against windpipe in the throat)
T4 (thyroxine)
T3 (triiodothyronine)


calcitonin
Metabolism




Regulate blood in calcium
Thyroid diseases (including hypo and hyperthyroidism)
Parathyroid
(located above or next to thyroid)
Parathyroid Hormone (PTH)  or Parathormone

Hyperparathyroidism

Hypoparathyroidism

Adrenal   
(2 organs on top of kidneys)
Epinephrine

Norepinephrine

Aldosterone 


Cortisol
Blood pressure regulation

stress reaction

Salt, water balance


Stress reaction

Pheochromocytopenia(MEN2)

Conn syndrome

Cushing syndrome


Addisons disease
Ovaries
(located on the pelvis)
Estrogen

Progesterone
Female sexual characteristics
Polycystic ovary syndrome (PCOS)
Testes
(located in the groin)
Testosterone
Male sexual characteristics
Hypogonadism
Pancreas
(located behind the stomach)
Insulin
Glucagon
Somatostatin
Glucose regulation   
Diabetes mellitus

MENI

Zollinger-Ellison syndrome


Pineal
(lower side of the brain)
Melatonin
Helps control sleep patterns



Did you know that Nervous system and Endocrine system work together?


You might wonder how this is possible? For our information, the endocrine and nervous system work together to attain a normal body function. The endocrine system in charge of the body processes of cell growth and development of different body organs of the body while breathing and movement of the body are controlled by the nervous system.

The hypothalamus which is the linked of the nervous system to the endocrine system via pituitary gland allows the release of hormones and is then circulated to different body organs. Here, we can see that the two major vital systems of our body work hand in hand to promote maintain a normal body function, our bodies normal function.





For us to understand more, please watch this video!


Reference:
http://www.blurtit.com/q1085214.html
http://wiki.answers.com/Q/How_does_the_nervous_and_endocrine_systems_work_together
http://labtestsonline.org/understanding/conditions/endocrine/start/2
Donald F. Calbreath, Clinical Chemistry a Fundamental Textbook
Henry's Clinical Diagnosis and Management by Laboratory Methods 21st Edition

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